Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Reductive evolution has endowed Mycobacterium tuberculosis (M. tb) with moonlighting in protein features. We exhibit that RipA (Rv1477), a peptidoglycan hydrolase, prompts the NFκB signaling pathway and elicits the manufacturing of pro-inflammatory cytokines, TNF-α, IL-6, and IL-12, via the activation of an innate immune-receptor, toll-like receptor (TLR)4. RipA additionally induces an enhanced expression of macrophage activation markers …

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation Read More »