Acute myocardial infarction (AMI) has changing into a standard main explanation for sudden dying worldwide. MiR-96 has been recognized that may goal anti-apoptotic associated genes in numerous human illnesses. However, its position in AMI stays unclear. In this examine, we discovered that miR-96 was considerably upregulated within the ischemic coronary heart of MI mice (mice with myocardial infarction) and likewise within the H2O2-treated neonatal rat ventricular cardiomyocytes (CMs). In response H2O2, miR-96 inhibitor might considerably promote cell viability and scale back cell apoptosis of CMs, and inhibit the expression of Cleaved caspase-Three and Bax, whereas promote Bcl-2 expression.
In addition, downregulation of miR-96 remarkedly decreased the infarct measurement and the odds of apoptotic cells within the coronary heart tissues of MI mice, after which protected towards the broken cardiac operate. Moreover, we recognized that XIAP (X-linked inhibitor of apoptosis) acted as a direct goal gene of miR-96, in the meantime si-XIAP might clearly reverse miR-96 inhibitor induced protecting impact in H2O2-treated CMs Taken collectively, our examine demonstrated that miR-96 promoted AMI development by instantly targeting XIAP, and inhibiting the anti-apoptotic operate of XIAP (Graphical summary), which offered a novel therapeutic goal for AMI therapy.
Deoxynivalenol (DON) is taken into account a mycotoxin that’s poisonous to the agricultural atmosphere and human physique. It is important to review the pathophysiological mechanism of DON toxicity on the mobile stage. Cytochrome c (Cyt c), as an necessary biomarker of DON-induced apoptosis that will result in a bipartite ‘point-of-no return’ occasion, is of nice significance to be detected utilizing cell imaging. Herein, we synthesized a DON-deactivated emission fluorescent probe, the molecularly imprinted polymer-coated quantum dots (CdTe@MIP), for monitoring the Cyt c stage with a photoinduced electron switch technique.
The CdTe@MIP probe may be simply loaded into cells and carry out nicely on account of its nice sensitivity and selectivity and its fluorescence was step by step quenched with the growing focus (0-10 μM) and incubation time (0-7.5 h) of DON. Cell imaging outcomes of apoptosis induced by DON was per that of the cell counting kit-Eight assay and movement cytometry method. The developed technique can be utilized to observe DON-induced apoptosis and supply an early-warning system for the contaminant toxicity.
Tanshinone IIA mixed with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion harm in overweight rats

Protective mechanism of kaempferol towards Aβ 25-35-mediated apoptosis of pheochromocytoma (PC-12) cells by means of the ER/ERK/MAPK signalling pathway
Factor Related Apoptosis (FAS) Antibody |
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20-abx104789 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx102355 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx102356 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx102357 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx102358 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx102359 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx102360 | Abbexa |
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Factor Related Apoptosis (Fas) Antibody |
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abx038135-100ug | Abbexa | 100 ug | EUR 391 |
Factor Related Apoptosis (FAS) Antibody |
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abx430025-200ul | Abbexa | 200 ul | EUR 384 |
Factor Related Apoptosis (FAS) Antibody |
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20-abx270037 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx270229 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx176352 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx172320 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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20-abx172321 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx129724 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody Pair |
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abx117346-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1010 |
Factor Related Apoptosis (FAS) Antibody Pair |
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20-abx370099 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx103238 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx103239 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx103240 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx103241 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx270062 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx270167 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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20-abx270335 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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20-abx270527 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (APC) |
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20-abx270567 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (APC) |
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20-abx270759 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (PE) |
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20-abx270799 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (PE) |
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20-abx270991 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx176353 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx176354 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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20-abx172322 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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20-abx273863 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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20-abx274177 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (Biotin) |
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20-abx271895 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (Biotin) |
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20-abx272642 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (Biotin) |
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20-abx273127 | Abbexa |
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Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Hu01 | Cloud-Clone |
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Description: Recombinant Human Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Hu02 | Cloud-Clone |
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Description: Recombinant Human Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Hu03 | Cloud-Clone |
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Description: Recombinant Human Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Po01 | Cloud-Clone |
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Description: Recombinant Pig Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Ra01 | Cloud-Clone |
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Description: Recombinant Rat Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Ra02 | Cloud-Clone |
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Description: Recombinant Rat Factor Related Apoptosis expressed in: E.coli |
Recombinant Factor Related Apoptosis (FAS) |
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4-RPA030Ra03 | Cloud-Clone |
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Description: Recombinant Rat Factor Related Apoptosis expressed in: E.coli |
Active Factor Related Apoptosis (FAS) |
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4-APA030Hu03 | Cloud-Clone |
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Description: Recombinant Human Factor Related Apoptosis expressed in: E.coli |
Eukaryotic Factor Related Apoptosis (FAS) |
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4-EPA030Ra61 | Cloud-Clone |
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Description: Recombinant Rat Factor Related Apoptosis expressed in: 293F cell |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Bovine) |
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4-PAA030Bo01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Bovine Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Human) |
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4-PAA030Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Human) |
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4-PAA030Hu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Human) |
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4-PAA030Hu03 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Mouse) |
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4-PAA030Mu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Pig) |
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4-PAA030Po01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Rat) |
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4-PAA030Ra01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Rat) |
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4-PAA030Ra02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Factor Related Apoptosis (FAS) |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Rat) |
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4-PAA030Ra06 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Factor Related Apoptosis (FAS) |
Factor Related Apoptosis Ligand (FASL) Antibody Pair |
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20-abx370039 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody Pair |
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20-abx370239 | Abbexa |
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Factor Related Apoptosis / CD95 / TNFRSF6 (FAS) Antibody |
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abx412230-50ug | Abbexa | 50 ug | EUR 509 |
Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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20-abx270360 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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20-abx270465 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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20-abx270592 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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20-abx270697 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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20-abx270824 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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20-abx270929 | Abbexa |
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Factor Related Apoptosis Ligand / TNFSF6 (FASLG) Antibody |
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abx233016-100ug | Abbexa | 100 ug | EUR 551 |
Factor Related Apoptosis Ligand / TNFSF6 (FASLG) Antibody |
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abx233017-100ug | Abbexa | 100 ug | EUR 509 |
Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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20-abx274189 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
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20-abx271896 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
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20-abx273435 | Abbexa |
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Recombinant Factor Related Apoptosis Ligand (FASL) |
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4-RPA031Hu01 | Cloud-Clone |
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Description: Recombinant Human Factor Related Apoptosis Ligand expressed in: E.coli |
Recombinant Factor Related Apoptosis Ligand (FASL) |
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4-RPA031Hu02 | Cloud-Clone |
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Description: Recombinant Human Factor Related Apoptosis Ligand expressed in: E.coli |
Recombinant Factor Related Apoptosis Ligand (FASL) |
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4-RPA031Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Factor Related Apoptosis Ligand expressed in: E.coli |
Recombinant Factor Related Apoptosis Ligand (FASL) |
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4-RPA031Ra01 | Cloud-Clone |
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Description: Recombinant Rat Factor Related Apoptosis Ligand expressed in: E.coli |
Recombinant Factor Related Apoptosis Ligand (FASL) |
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4-RPA031Si01 | Cloud-Clone |
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Description: Recombinant Simian Factor Related Apoptosis Ligand expressed in: E.coli |
Rat Factor Related Apoptosis (FAS) Protein |
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20-abx651484 | Abbexa |
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Monkey Factor Related Apoptosis (FAS) Protein |
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20-abx653333 | Abbexa |
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Human Factor Related Apoptosis (FAS) Protein |
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20-abx066477 | Abbexa |
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Mouse Factor Related Apoptosis (FAS) Protein |
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20-abx066478 | Abbexa |
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Rat Factor Related Apoptosis (FAS) Protein |
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20-abx066479 | Abbexa |
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Mouse Factor Related Apoptosis (FAS) Protein |
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20-abx066480 | Abbexa |
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Rat Factor Related Apoptosis (FAS) Protein |
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20-abx066481 | Abbexa |
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Human Factor Related Apoptosis (FAS) Protein |
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20-abx066482 | Abbexa |
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Rat Factor Related Apoptosis (FAS) Protein |
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20-abx066483 | Abbexa |
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Human Factor Related Apoptosis (FAS) Protein |
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20-abx166447 | Abbexa |
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Pig Factor Related Apoptosis (FAS) Protein |
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20-abx167536 | Abbexa |
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Cow Factor Related Apoptosis (FAS) Protein |
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20-abx168020 | Abbexa |
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Porcine Factor- related Apoptosis ELISA Kit |
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ELA-E0030p | Lifescience Market | 96 Tests | EUR 928 |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Bovine), APC |
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4-PAA030Bo01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Bovine Factor Related Apoptosis (FAS). This antibody is labeled with APC. |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Bovine), Biotinylated |
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4-PAA030Bo01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Bovine Factor Related Apoptosis (FAS). This antibody is labeled with Biotin. |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Bovine), Cy3 |
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4-PAA030Bo01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Bovine Factor Related Apoptosis (FAS). This antibody is labeled with Cy3. |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Bovine), FITC |
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4-PAA030Bo01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Bovine Factor Related Apoptosis (FAS). This antibody is labeled with FITC. |
Factor Related Apoptosis (FAS) Polyclonal Antibody (Bovine), HRP |
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4-PAA030Bo01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Bovine Factor Related Apoptosis (FAS). This antibody is labeled with HRP. |
This examine demonstrated that kaempferol protected PC-12 cells from Aβ25-35-induced cell dying and apoptosis in a dose-dependent method. Treatment with fulvestrant (an antagonist of ER) and U0126 (an inhibitor of ERK) considerably elevated the apoptosis of PC-12 cells. Moreover, kaempferol promoted the expression of anti-apoptotic molecules and inhibited the expression of pro-apoptotic molecules, which have been blocked by fulvestrant and U0126. Kaempferol is a flavonoid phytoestrogen that may produce a sure protecting impact in neurons. However, the molecular mechanism of kaempferol in AD is unclear.