Month: June 2021

MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP

MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP

Acute myocardial infarction (AMI) has changing into a standard main explanation for sudden dying worldwide. MiR-96 has been recognized that may goal anti-apoptotic associated genes in numerous human illnesses. However, its position in AMI stays unclear. In this examine, we discovered that miR-96 was considerably upregulated within the ischemic coronary heart of MI mice (mice …

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Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Reductive evolution has endowed Mycobacterium tuberculosis (M. tb) with moonlighting in protein features. We exhibit that RipA (Rv1477), a peptidoglycan hydrolase, prompts the NFκB signaling pathway and elicits the manufacturing of pro-inflammatory cytokines, TNF-α, IL-6, and IL-12, via the activation of an innate immune-receptor, toll-like receptor (TLR)4. RipA additionally induces an enhanced expression of macrophage activation markers …

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation Read More »